010-59520072
Chinese Academy of Sciences Beijing Institute of Translational Medicine
研究院简介

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  李岩(技术)博士 研究员 博士生导师

  中科院生物物理所,交叉科学所重点实验室,创新课题组组长

  研究方向:蛋白质组学和糖组学的生物学和临床医学的研究

  电子邮件(E-mail ) yanli@ibp.ac.cn

  电话(Tel) 010-64885759

  传真(Fax) 010-64871293

  邮政编码 100101

  英文版个人网页

  简历 & 研究组摘要

  1994-1998 北京大学医学部(原北京医科大学)药学系,学士

  2000-2004 美国马里兰大学化学和生物化学系,博士

  2004-2005 美国Calibrant Biosystems生物技术公司,技术研发科学家

  2005-2011 美国约翰霍普金斯大学医学院病理系,博士后/research associate

  2011-今 中科院生物物理研究所研究员,博士生导师

  研究方向

  主要从事蛋白质组学和糖组学的生物学和临床医学的研究。研究方向主要包括以下三个方向:

  (1)开发以生物质谱为核心的多种蛋白质组学的分析技术和方法;

  (2)发展适用于生物样品和临床样品的新型糖组学的分析技术和方法;

  (3)在蛋白质组学和糖组学分析技术的基础上,主要开展针对蛋白质及其翻译后修饰的表达调控及其在人体功能和临床疾病中的作用机制的研究。

  代表性论文

  1. Li Y, Wang X, Ao M, Gabrielson E, Askin F, Zhang H, Li QK.“Aberrant,Mucin5B expression in lung adenocarcinomas detected by iTRAQ labeling quantitative proteomics and immunohistochemistry.” Clinical Proteomics. (2013)1;10(1):1

  2. Li QK, Shah P, Li Y, Aiyetan PO, Chen J, Yung R, Molena D, Gabrielson,E, Askin F, Chan DW, Zhang H.“Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma.”J Proteome Res. (2013)2;12(8):3689-96.

  3. Yang,S.,Li,Y.,Shah,P.,Zhang,H.,“ Glycomic analysis using glycoprotein immobilization for glycan extraction” Analytical Chemistry, (2013)4;85(11):5555-61.

  4. Li, Y., Tao, S.C., Bova, S.G., Liu, A.Y., Tian, Y., Chan, D. W., Zhu, H., Zhang, H. “Detection and Verification of Glycosylation Patterns of Glycoproteins from Clinical Specimens Using Lectin Microarrays and Lectin-based Immunosorbent Assays” Analytical Chemistry, (2011)15;83(22):8509-16.

  5. Li, Y., Tian, Y., Rezai, T., Prakash, A., Lopez, F.M., Chan, D. W., Zhang, H. “Simultaneous Analysis of Glycosylated and Sialylated PSA Reveals Differential Distribution of Glycosylation PSA Isoforms in Prostate Cancer Tissues”. Analytical Chemistry. (2011)1;83(1):240-5.

  6. Li, Y., Zhang, H. “High Throughput Analysis of Glycoproteins from Plasma”. Methods Mol Biol. (2011);728:125-33.

  7. Li, Y., Sokoll, L., Rush, J., Zou, N., Chan, D. W., Zhang, H. “ Targeted detection of prostate cancer proteins in serum using heavy peptide standards and MALDI-TOF/TOF”. Proteomics-Clinical Application (2009) 3, 597-608.

  8. Li, Y., Sokoll, L. J., Barker, P. E., Chan, D. W., Zhang, H., “Mass spectrometric identification of proteotypic peptides from clinically used tumor markers”, Clinical Proteomics, (2008) 4:58-66.

  9. Li, Y., DeVoe, D. L., Lee, C. S., “Microfluidics-Based Proteome Analysis,” in Proteomics for Biological Discovery (T.D. Veenstra, J.R. Yates eds.), John Wiley & Sons, p.205, (2006).

  10. Li, Y., Buch, J. S., Rosenberger, F., DeVoe, D. L., Lee, C. S., “Integration of Isoelectric Focusing with Parallel SDS Gel Electrophoresis for Multidimensional Protein Separations in a Plastic Microfluidic Network”, Anal. Chem. 76, 742 (2004).

  11. Cooper, J. W., Chen, J., Li, Y., Lee, C. S., “Membrane-Based Nanoscale Proteolytic Reactor Enabling Protein Digestion, Peptide Separation, and Protein Identification Using Mass Spectrometry”, Anal. Chem. 75, 1067 (2003).

  12. Li, Y., DeVoe, D. L., Lee, C. S., “Dynamic Analyte Introduction and Focusing in Plastic Microfluidic Devices for Proteomic Analysis”, Electrophoresis 24, 193 (2003).

  专利

  1. 02/03/2011  Zhang, H., Danni, L. Meany, Li, Y., Sokoll, L.J., Zhang, Z., and Chan, D.W. Detection of prostate cancer using PSA glycosylation patterns. The Johns Hopkins University. (United States Patent US2009004365)

  2. 01/28/2010 Zhang, H., Danni, L. Meany, Chan, D.W., Zhang, Z., Li, Y., Sokoll, L.J. Detection of prostate cancer using PSA glycosylation patterns. The Johns Hopkins University. (United States Patent US2009004365)

  3. 08/31/2006 DeVoe, D. L, Wang, Y, Lee, C. S. Li, Y. Methods and apparatus for porous membrane electrospray and multiplexed coupling of microfluidic systems with mass spectrometry. Calibrant Biosystems. (United States patent 20060192107)

  4. 10/07/2011 Zhang, H., Li, Y., Sokoll, L.J., Zhang, Z., and Chan, D.W. Biomarker for Prostate Cancer. The Johns Hopkins University. United State Patent 20100255472

  5. 06/04/2007  Zhang, H., Li, Y., Sokoll, L.J., Zhang, Z., and Chan, D.W. Detection of prostate cancer proteins in serum for cancer diagnosis with a blood test. The Johns Hopkins University. (pending)


【官网】中国科学院北京转化医学研究院
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